Research progress on drugs targeting p53
10.3969/j.issn.1001-1978.2014.07.007
- VernacularTitle:靶向作用p53药物的研究进展
- Author:
Xiaoli DAI
;
Jing LIU
;
Ying LUO
;
Jihong ZHANG
- Publication Type:Journal Article
- Keywords:
targeted drug development;
targeted gene;
antineo-plastic agents;
p53 gene;
conformational change;
p53-MDM2 interaction;
compound mechanism
- From:
Chinese Pharmacological Bulletin
2014;(7):912-916
- CountryChina
- Language:Chinese
-
Abstract:
With the understanding of the development and pro-gress of the cancer,the research of targeted cancer drug devel-opment reaches into a new era.p53 is an important tumor sup-pressor gene,the protein coded by p53 plays a critical role in tumor suppression mainly by inducing cell cycle regulation, DNA repair and apoptosis.Nowadays,p53 becomes a relatively attractive target for anti-cancer drug development and there are some drugs targeting p53,moreover,APR-246 which targets mutant p53 is in Phase II clinical trial.In addition,it facilitates drugs discovery programmes in the challenging area of protein-protein interactions and mutant protein conformational change. The review discusses the research progress of drugs which target p53 and elucidates the characteristics and mechanisms of these compounds.
