Tissue distribution on a novel derivate of all-trans-retinoic acid,ATPR
10.3969/j.issn.1001-1978.2014.07.022
- VernacularTitle:新型维甲酸衍生物ATPR大鼠体内组织分布的研究
- Author:
Xia ZHAN
;
Feihu CHEN
;
Jihui TANG
;
Jinfang GE
;
Yayun XU
;
Guanru CHEN
;
Xiaoqing PENG
- Publication Type:Journal Article
- Keywords:
4-amino-2-trifluoromethyl-phenyl reti-nate;
novel derivate of all-trans-retinoic acid;
HPLC;
tissue distribution;
rat;
intravenous administration;
in-tragastric administration
- From:
Chinese Pharmacological Bulletin
2014;(7):985-988
- CountryChina
- Language:Chinese
-
Abstract:
Aim To develop a sensitive,specific and accurate method for quantifying a novel derivate of all-trans-retinoic acid, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR)in rat tissues to investigate the tissue distribution of ATPR in rats.Methods Sprague-Daw-ley (SD)rats were killed by exsanguination at 2,4,7 h after a single intragastric administration with one dose of ATPR (20 mg·kg-1 )or at 5 min,1 h,5 h after a single intravenous administration with one dose of AT-PR (7 mg·kg-1 ).The concentration of ATPR in the tissues was determined by high performance liquid chromatography (HPLC)method.Results After the rats were administrated intragastrically, the highest concentration of ATPR was observed in intestine,fol-lowed by liver,spleen and lung,while the distribution in heart,kidney,fat and brain was very little.Howev-er,the highest concentration of ATPR was in liver after given intravenously,followed by spleen and lung,and very low in heart,kidney,intestines,fat and brain. Conclusion The distribution of ATPR is higher in liv-er after administrated both intragastrically and intrave-nously,suggesting the potential anti-proliferation and differentiation inducing effects of ATPR targeting at liv-er cancer.
