Influence on Glycolipid Metabolism, Neuron and Microvascular by Chinese Medicine Dai-Xie-An Granules among Aging Rats of Metabolic Syndrome
10.11842/wst.2014.06.018
- VernacularTitle:代谢安颗粒对老龄代谢综合征大鼠糖脂代谢、神经元及微血管的影响
- Author:
Haibin YU
;
Min ZHAO
;
Jiansheng LI
- Publication Type:Journal Article
- Keywords:
Dai-Xie-A n granules;
metabolic syndrome;
neuron;
microvascular;
rat
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(6):1305-1312
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the therapeutic effect of Chinese medicine Dai-Xie-A n (DXA) granules a-mong aging rats of metabolic syndrome (MS) in order to evaluate relative indicators and the pathophysiological role in neurons and microvascular injury among aging MS rats. Aging MS rat model was established by feeding high-fat diet and the established model was evaluated. Under the guidance of traditional Chinese medicine (TCM) theory, metabol-ic indexes, such as general state of health, glycolipid metabolism, insulin sensitivity, were explored in order to ob-serve effects on brain neurons and microvascular injury among aging MS rats. The results showed that DXA granules can improve glycolipid metabolism among aging MS rats, decrease TC, TG, TC/HDL, decrease the level of blood sug-ar and serum insulin, improve insulin resistance, decrease abdominal fat accumulation, reduce neuronal apoptosis, and increase microvascular angiogenesis. These effects are similar to rosiglitazone. It was concluded that DXA gran-ules can ameliorate glycolipid disorders, protect brain neurons and microvascular injury of aging MS rats.
