Experimental Study on Synergistic and Attenuated Effect of Ginseng Polysaccharide Injection among Animals Treated with Cytoxan
10.11842/wst.2014.06.029
- VernacularTitle:人参多糖注射液对环磷酰胺增效减毒作用实验研究
- Author:
Xinyong LYU
;
Jun ZHOU
;
Xiaoping SUN
;
Lina LIU
;
Zhenzhong WANG
;
Wei XIAO
- Publication Type:Journal Article
- Keywords:
Ginseng polysaccharide injection;
CTX;
toxicity-reducing;
ICR mice with S180 cells
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(6):1372-1376
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the inhibitory effect of ginseng polysaccharide injection on tumor growth a-mong ICR mice after inoculation of S180 cells, and its immune mechanism as well as its synergic effect in reducing toxicity of cytoxan (CTX). The experiment was carried out in ICR mice after inoculation of S180 cells. The mice were randomly divided into the model group, the control group, the CTX group, and the drug combination group. After 10 days of medication, the inhibition of tumor growth, WBC, thymus index and spleen index were measured in mice dur-ing the experiment. The immunodepressed mice model was induced by CTX. Effects of ginseng polysaccharide injec-tion on serum hemolysin and monomuclear macrophage phagocytosis were evaluated. The results showed that the com-bination of ginseng polysaccharide injection and CTX can significantly increase the tumor inhibiting rate. It can also reduce the side effect and toxicity of CTX, which may improve the immunosuppression induced by CTX. It was con-cluded that ginseng polysaccharide injection can increase the therapeutic effects and reduce the toxicity of CTX.
