Activity-based Studies on Chemical Constituents in Tragopogon Porrifolius L.

VernacularTitle:菊参化学成分及其药理活性探析
Author: Hongmei CUI ; Heng LUO ; Andong YANG ; Wanshou LI
Publication Type:Journal Article
Keywords: Tragopogon porrifolius L.; 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid; adenine; isolation; structure identification; pharmacological activity
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(6):1434-1437
CountryChina
Language:Chinese
Abstract: This article was aimed to study the chemical constituents in Tragopogon porrifolius L. and their activities by pharmacological experiment in order to provide evidences in the further development of the usage of this medical resource. Under the guidance of pharmacological activities screening results, compounds were isolated by repeated silica gel, macroporous resin column chromatography and HPLC. Their structures were identified by means of UV, IR, MS, NMR and other chemical evidences. The results showed that T. porrifolius L. (i.e., n-butanol extraction part) can increase survival time of mice in the oxygen-lacking state (P < 0.05). Two compounds of biological alkaloids, which were identified as 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (Ⅰ) and adenine (II), were isolated. It was concluded that compound Ⅰ and II were obtained from T. porrifolius L. for the first time.