Biological Effects and Traits on Acute Adjuvant Arthritis of Rats Treated withSemiconductor Laser Irradiation on ST36-Zusanli
10.11842/wst.2014.06.015
- VernacularTitle:半导体激光照射足三里穴对大鼠急性佐剂性关节炎的生物效应及作用
- Author:
Xiaochen WENG
;
Huayuan YANG
- Publication Type:Journal Article
- Keywords:
Semiconductor laser;
acute adjuvant arthritis;
biological effect;
cumulative effect;
parabolic characteristic
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(6):1287-1293
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to compare the difference of treatment on acute adjuvant arthritis (AA) by using dif-ferent energy densities withirradiation on ST36-Zusanli under the fixed wavelength (650 nm) by the semiconductor. Biological effect and traits of the laser irradiation were also studied. A total of 60 healthy male SD rats were random-ly divided into the normal control group, model group, low energy density group (61.89 J/cm2)and high energy density group (247.57 J/cm2). The Freund's complete adjuvant (FCA) was intradermallyinjected into rats' right hind paw to establish AA rat model. The treatment group was treated with 650nm semiconductor laser irradiation on ST36-Zu-sanli with the energy density of 61.89 J/cm2 and 247.57 J/cm2, respectively. The joint swelling degree, pain thresh-old, TNF-α and IL-1β level changes were observed on thefirst, third and fifthtreatment after modeling. The results showed that compared with the normal group, the joint swelling degree, pain threshold, TNF-α, and IL-1β were obvi-ously increased in the model group (P<0.05). After five times treatment, the semiconductor laser with low and high energy density had effect on acute inflammation. And the high energy density treatment effect had a better effect than the low energy density one (P<0.05). It was concluded that the energy density of 61.89 J/cm2 and 247.57 J/cm2 of semiconductor laser irradiation on ST36-Zusanli can relieve acute inflammatory pain and swelling caused by AA; re-duce the TNF-α and IL-1β concentration levels. Semiconductor laser irradiation had the characteristics of stimula-tion or inhibition, cumulative effect and parabola. Low energy density group obtained the best effect between the third and fifth treatment.
