Study on Anticoagulant Activity in Vivo of Active Component F2-2 from Eupolyphaga seu Steleophaga

VernacularTitle:土鳖虫活性组分F2-2体内抗凝药效实验
Author: Zhenlin HUANG ; Liangying HE ; Hongtao WANG ; Shaohua ZHAO ; Yurong WANG
Publication Type:Journal Article
Keywords: Eupolyphaga sinensis Walker; anticoagulant component; F2-2; anticoagulant activity
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(6):1359-1363
CountryChina
Language:Chinese
Abstract: Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), plasma fibrino-gen (FIB), platelet aggregation rate and blood clots-fibrinolytic dynamic figure were taken as indexes in the evalua-tion of anticoagulant activity in vivo of active component F2-2 from Eupolyphaga seu Steleophaga. After 5 days of hypodermic injection of adrenaline, the rat model of acute blood stasis was established. Indexes were determined af-ter the model rats were treated with an intragastric administration of F2-2 for 9 days. The results showed that com-pared with the model group, PT/APTT was prolonged, FIB content was decreased, platelet aggregation rate and the largest of blood coagulation were declined after 9 days of intragastric administration in the model group. However, there was no difference on TT. It was concluded that the anticoagulant component F2-2 separated from E. seu Steleophaga showed favorable anticoagulant activity in vivo. However, its mechanism remained unknown and request-ed further researches.