Features of circulating Th17 cells in chronic HBV infection patients whole responsed to pegylated in-terferon α-2a treatment
- VernacularTitle:聚乙二醇α-2a干扰素治疗完全应答 HBV 感染患者外周血 Th17细胞变化的研究
- Author:
Chunhui SONG
;
Yuanyuan LI
;
Liming CHEN
;
Jiyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Pegylated interferon α-2a;
HBV;
Th17 celll
- From:
Journal of Chinese Physician
2010;(z2):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To invetigate the feature of Th 17 cells in chronically HBV-infected patients whole responsed to pegylated interferon α-2a treatment.Methods Serum and PBMCs were obtained from enrolled CHB patients and health controls and monitored for ALT , HBV DNA, HBV Markers as well as the frequency of IL-17 +T cells.Results The frequency of IL-17 +,IL-17 +IFN-γ+and IL-17 +IFN-γ-T cells increased in whole response time point and decreased in followed 6 month ;and lower than that of health controls at any group .Conclusion Tteatment with pegylated interferon α-2a minght effect the fre-quency and composition of Th 17 cells, which effect the immune regulation in the disease .
