The evaluation of myocardial infarction with dual-energy myocardial perfusion by using the second-generation dual-source CT:an experimental study in pig phantom
10.3969/j.issn.1004-8812.2014.06.011
- VernacularTitle:第二代双源CT双能量心肌灌注评价猪心肌梗死的实验研究
- Author:
Ruiping ZHAO
;
Yaojun LU
;
Hongyu LI
;
Kai SUN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Myocardial perfusion;
The second generation dual-source CT
- From:Chinese Journal of Interventional Cardiology
2014;(6):384-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluated the feasibility and accuracy of obtaining the myocardial perfusion image and coronary artery image of pig models of acute myocardial infarction by the second generation dual-source CT dual-energy myocardial perfusion one-stop scanning. Methods The pig models of acute myocardial infarction was established by using the interventional gelatin sponge embolism method on 5 pigs. The myocardial perfusion scanning and coronary angiography were respectively used 20 min before and 24-48 h after modeling. The heart were taken out immediately after the inspection for multiple punch biopsy and HE staining, then the heart was sliced for triphenyltetrazolium chloride (TTC) staining. According to the gold standard of coronary angiography and pathological staining, the sensibility and speciifcity of the coronary artery image of acute myocardial infarction of pig reconstructed by myocardial perfusion scanning and the myocardial perfusion image were respectively evaluated, and the consistency of the results was veriifed by Kappa test. Results Compared with the pathologic gold standard, the sensitivity, speciifcity, of myocardial perfusion iodine image obtained by myocardial perfusion scanning were 93%, 91%; and Kappa value was 0.68. Compared with the coronary angiography gold standard, the sensitivity and speciifcity of coronary artery image obtained by myocardial perfusion scanning were 93%, 81%, and Kappa value was 0.71. Conclusions The second generation dual-source CT dual-energy myocardial perfusionone-stopscanning can accurately get the coronary artery and myocardial perfusion images of the pig models of acute myocardial infarction.
