The changes and significance of the extracellular matrix in larynx of old guinea pig

VernacularTitle:老年豚鼠喉部细胞外基质成分的改变和意义
Author: Cuie LI ; Tao ZHOU ; Zezhang TAO ; Na ZHAN
Publication Type:Journal Article
Keywords: Hyaluronic acid; Collagenases; Sound
From: Chinese Journal of Geriatrics 2014;33(7):807-809
CountryChina
Language:Chinese
Abstract: Objective To study the changes and significance of the hyaluronic acid (HA) and collagen in the larynx of old guinea pig.Methods Six young guinea pigs (4 months old) and 6 old guinea pigs (2 years old) were selected as control group and aged group for this study (n=6 for each)The expressions of HA and collagen in the larynx of guinea pigs were detected using Alcian blue and Masson trichrome methods,respectively.The images were managed using Image-Pro Plus 6.0 For Window.Results The optical density (expression level) of HA in the larynx was lower in aged group than in control group (0.69 vs.0.80,F=13.45,P＜0.05).The optical density(expression level) of collagen in the larynx was higher in aged group than in control group (0.71 vs.0.63,F=9.56,P＜0.05).Conclusions The content of HA in larynx is decreased and collagen in larynx is increased in old guinea pig which may result in presbyphonia change through higher viscoelastic properties of vocal cords.