Advance on structural change of the heart during severe sepsis
10.3760/cma.j.issn.1673-4912.2014.07.018
- VernacularTitle:严重脓毒症心脏结构改变的研究进展
- Author:
Mingxia SHANG
;
Xiao HAN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Inflammation;
Apoptosis;
Mitochondria
- From:
Chinese Pediatric Emergency Medicine
2014;21(7):455-457
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular dysfunction is common in severe sepsis.Although functional alteration is often described,the elevated serum levels of cardiac proteins and autopsy findings of myocardial immune cell infiltration,edema,and damaged mitochondria suggest that structural changes to the heart during severe sepsis may occur and may contribute to cardiac dysfunction.Myocardial functions may be improved by pretreatment with plateletactivating factor,cyclo-sporin A,glutamine,caffeine,simvastatin,or caspase inhibitors.We explored the advance on structural change of the heart during severe sepsis in order to deepen the understanding of these changes.
