The clinical effect of losartan combined with metoprolol tartrate in treatment of elderly patients with coro-nary heart failure and its effect on heart function, plasma brain natriuretic peptide and hemorheology
10.3760/cma.j.issn.1008-6706.2014.16.020
- VernacularTitle:氯沙坦联合美托洛尔治疗老年人冠心病心力衰竭的疗效及对患者心功能、血浆脑钠肽和血液流变学指标的影响
- Author:
Ming YE
;
Shaoping NIE
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Heart failure,congestive;
Natriuretic peptide,brain;
Losartan;
Metoprolol tar-trate;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(16):2441-2443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of losartan combined with metoprolol tartrate in treat -ment of elderly patients with coronary heart failure and its effect on heart function ,plasma brain natriuretic peptide and hemorheology.Methods 88 elderly patients with coronary heart failure were randomly divided into two groups ,and 44 cases were in each group .All of the patients were given conventional treatment , and the control group was given losartan while the observation group was received metoprolol tartrate on the basis of the control group ,the clinical effi-cacy and effect on cardiac function ,plasma brain natriuretic peptide ,hemorheology indexes were compared between the two groups.Results The total effective rate of the observation group was 95.45% significantly higher than 77.27%of the control group (χ2 =7.728,P<0.05);cardiac function and plasma BNP were significant improvement compared with the control group(t=6.55,6.02,7.41 and 13.24,all P<0.05);after the treatment,except the plate-let adhesion rate ,the hemorheology of the observation group were significant improvement compared with the control group(t=7.84,7.32,6.55,7.02,5.89 and 5.70,all P<0.05).Conclusion Losartan combined with metoprolol tartrate in treatment of coronary heart failure is significant effect ,and it can effectively improve the patient′s cardiac function,plasma brain natriuretic peptide levels and blood rheology ,and it is worth to be applied in clinical .
