Relationship between serum 25-hydroxy vitamin D3 level and function of islet beta cell in newly diagnosed type 2 diabetes
10.3760/cma.j.issn.1008-6706.2014.16.042
- VernacularTitle:初诊2型糖尿病患者血清25-羟维生素 D3水平与胰岛β细胞功能的关系
- Author:
Shuguo SUN
;
Meng QIN
;
Mei XUE
- Publication Type:Journal Article
- Keywords:
diabetes,type 2;
25-hydroxy vitamin D3;
Insulin resistance index;
islet beta cell secrete index
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(16):2494-2495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the serum 25-hydroxy vitamin D 3 level in newly diagnosed type 2 diabe-tes,and its relationship with function of islet beta cell .Methods 60 newly diagnosed type 2 diabetes patients and 48 normal glucose tolerance healthy control cases were selected .The level of serum 25-hydroxy vitamin D3 of two groups were measured using the way of high performance liquid chromatograph .The difference was compared between two groups.Insulin resistance index(HOMA-IR) and islet beta cell secrete index(HOMA-β) was used to respectively es-timate insulin sensitivity and islet beta cell function in type 2 diabetes group .The correlation was analyzed between 25-hydroxy vitamin D 3 and fasting blood glucose ,HOMA-IR,HOMA-β.Results The level of serum 25-hydroxy vita-min D3 (28.68 ±1.61) ng/mL in type 2 diabetes group was significantly lower than that of control group (41.30 ± 1.12)ng/mL(t=3.47,P<0.01).There is negative correlation between 25-hydroxyl vitamin D3 and fasting glucose (r=0.48,P<0.05).There was positive correlation between 25-hydroxy vitamin D3 and HOMA-IR(r=0.52,P<0.05).There was no correlation between 25-hydroxy vitamin D3 and HOMA-β(r=-0.06,P>0.05).Conclusion The level of 25-hydroxy vitamin D 3 was significantly low in newly diagnosed type 2 diabetes patients .Low serum 25-hydroxyl vitamin D 3 level affects islet beta secretion cell function ,the supplementation of vitamin D 3 may be a simple and effective method to reduce the ocurrence of type 2 diabetes .
