The effect of Shuxuening intra-articular injection in the treatment of osteoarthritis and its influence on cyto-kines in synovial fluid
10.3760/cma.j.issn.1008-6706.2014.15.036
- VernacularTitle:关节腔内注射舒血宁治疗骨性关节炎的疗效及对关节液细胞因子的影响分析
- Author:
Guiyun HUANG
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
Shuxuening injection;
Interleukin-1 beta;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(15):2319-2320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shuxuening intra-articular injection in the treatment of osteoarthritis and its infullence on cytokines in synovial fluid .Methods According to the digital table ,120 patients with osteoarthritis were randomly divided into two groups ,60 cases in each group.The observation group received Shuxuening injection in articular cavity treatment ,and the control group was given sodium hyaluronate .The efficacy and levels of interleukin-1(IL-1) and tumor necrosis factor alpha(TNF-α) in synovial fluid were compared between the two groups.Results After treatment,the score in the observation group was significantly lower than that of the control group(t=16.282,P<0.05).The total effective rate of the observation group was 95.0%,which was signifi-cantly higher than 81.7%of the control group(χ2 =5.175,P<0.05).After treatment,the IL-1βand TNF-αlevels of the observation group were significantly lower than those of the control group (t =4.95,6.656,all P<0.05). Conclusion Shuxuening intra-articular injection in the treatment of osteoarthritis can not only alleviate the symp-toms,improve the curative effect ,but also can reduce the IL-1 βand TNF-αlevels in synovial fluid .
