Research on the efficacy and safety of insulin glargine in different administration time for treatment of type 1 diabetes
10.3760/cma.j.issn.1008-6706.2014.15.032
- VernacularTitle:甘精胰岛素不同给药时间治疗1型糖尿病的疗效及安全性研究
- Author:
Ying LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 1;
Insulin glargine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(15):2310-2311
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of insulin glargine in different administra-tion time for treatment of type 1 diabetes .Methods 50 patients with type 1 diabetes were given insulin aspart and in-sulin glargine treatment scheme , under the premise of not change insulin glargine dosage , delivery time of insulin glargine varied from 22:00 to 18:00,and fasting blood glucose(FBG),2 hours postprandial blood glucose(2hPG), blood glucose and occurrence of hypoglycemia before lunch , amount of insulin aspart were noted and compared between before and after the adjustment .Results After adjustment of insulin glargine′s medication time , patients′blood sugar before lunch adjusted to desired level ,FBG(7.28 ±2.13) mmol/L vs.(8.33 ±2.20) mmol/L,2hPG (8.61 ±2.59)mmol/L vs.(9.70 ±1.75) mmol/L decreased significantly after lunch compared with pre-adjustment (U=2.425,3.034,all P<0.05),2hPG after breakfast (8.27 ±2.02) mmol/L vs.(8.56 ±2.33) mmol/L and dinner 2hPG (9.54 ±1.55)mmol/L vs.(9.61 ±1.75)mmol/L without statistically significant difference (all P>0.05).Dosage of insulin aspart before breakfast reduced , and increased before lunch and dinner .Incidence of hypoglycemia before lunch significantly decreased (χ2 =4.105,5.005,all P<0.05).Conclusion Insulin glargine combined with insulin aspart in the treatment of type I diabetes ,with no change in insulin glargine dosage ,and delivery time changed from 22:00 to 18:00,which could reduce FBG ,reduce occurrence of hypoglycemia before lunch ,and stable in blood sugar controlling .
