The relationship between the degree of intracranial and extracranial arterial stenosis and the plasma level of homocysteine in patients with ischemic cerebrovascular disease
10.3760/cma.j.issn.1008-6706.2014.15.033
- VernacularTitle:缺血性脑血管病患者颅内外动脉狭窄程度与血浆同型半胱氨酸水平的相关性分析
- Author:
Wenguang BU
;
Kun QIAN
;
Tao WANG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Intracranial arterial diseases;
Homocysteine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(15):2312-2314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the degree of intracranial and extracranial arterial stenosis and the plasma level of homocysteine ( Hcy ) in patients with ischemic cerebrovascular disease .Methods 96 patients with ischemic cerebrovascular disease were checked by DSA .The distribution of stenosis in the studied cerebral arteries was analyzed .According to the degree of stenosis ,all 96 patients were divided into some groups ,at the same time Hcy level was detected ,and the correlation between Hcy level and intracranial and extracranial artefial stenosis were analyzed .Results 35 of the 96 patients had normal findings in angiography ,and 61 cases had occlusive lesions of different degrees .The mean plasma Hcy concentration in patients with intracranial and extracranial arterial stenosis was 19.26 (14.79~26.13)μmol/L,which was significantly higher than 11.60(8.8~15.11)μmol/L in the patients with no arterial stenosis (P<0.05).There was a significant positive correiation between Hcy level and cerebral artery stenosis degree(r=4.126,P<0.05).Conclusion The plasma Hcy level was positively correlated with intracranial and extracranial arterial stenosis in patients with ischemic cerebrovascular disease ,incidence and nar-row-degree of cerebral artery stenosis are all along with the increasing of Hcy level .
