Changes and clinical significance of serum IL-1, IL-6 and TGF-β1 in patients with knee osteoarthritis

VernacularTitle:膝骨性关节炎患者血清白细胞介素-1、6和转化生长因子-β1水平的变化及意义
Author: Jianhong LIANG
Publication Type:Journal Article
Keywords: Osteoarthritis,Knee; Interleukin-1; Interleukin-6; Transforing growth factor beta
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(16):2428-2429
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical significance of changes of serum IL-1,IL-6 and TGF-β1 in pa-tients with Knee osteoarthritis(KOA).Methods Serum IL-1,IL-6 and TGF-β1 levels were measured by ELISA in 100 patients with KOA and 100 health control .Results The KOA group serum IL-1 and IL-6 levels were higher than those of the healthy control group (t=71.132,t=78.503,all P<0.01),while the level of TGF-β1 was converse(t=36.165,P<0.01);The levels of serum IL-1 and IL-6 increased gradually with the increase of the severity ,while.the level of TGF-β1 was decreased;the serum level of TGF-β1 was negative correlation with the level of IL-6,IL-8 in patients with KOA(r=-0.633,r=-0.615,all P<0.05),the serum level of IL-1 was positive correlation with the level of IL-6(r=0.730,P<0.01).Conclusion The serum IL-6,IL-8 and TGF-β1 reflect situation of patients and extent of Joint injury ,which is close relationship between the clinical process of KOA and has significance value to evaluate the pathogenetic condition and prognosis .