Clinical observation of participation NOTES injection combined with chemotherapy in the treatment of small cell lung cancer
10.3760/cma.j.issn.1008-6706.2014.16.031
- VernacularTitle:参附注射液联合化疗治疗小细胞肺癌的临床观察
- Author:
Jitian WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,small cell;
Shenfu Injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(16):2468-2470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of shenfu injection combined with chemotherapy in the treatment of small cell lung cancer .Methods 100 cases of patients with small cell lung cancer were randomly di-vided into control group and observation group using the number table ,each group was 50 cases.The control group was given only gemcitabine +carboplatin treatment,and the observation group was given 60ml shenfu injection twice per day on the basis of the control group ,and it continued 10d.Two groups of a course of treatment was three weeks . Changes in lymphocyte subsets , the incidence of postoperative complications , quality of life and lung function were compared before and after treatment .Results The clinical total effective rate of control group was 54.0%,which was significantly lower than that of the observation group (86.0%),the difference existed a statistical significant difference (χ2 =8.36,P<0.05).Changes in lymphocyte subsets before and after treatment between the control group and the observation group,the differences were statistically significant (t1=5.36,5.12,4.68,5.68,4.78,t2=5.28,5.13, 5.68,4.12,4.66,all P<0.05) after treatment,the observation group than the control group ,the difference was sta-tistically significant(t=5.22,5.73,4.56,5.03,4.85,all P<0.05);The rate of postoperative complications in the contro group was 16.0%,14.0%in the observation group ,the difference existed no statistical difference (χ2 =2.13, P>0.05).According to the SGQR scoring standads ,there was a statistical difference between the two groups ( t=4.29,5.34,4.93,6.22,all P<0.05).There was a statistical difference of pulmonary function (FEV1,FEV1%,FVC and 6MWD) between the two groups(t=4.19,5.23,4.52,4.39,all P<0.05).Conclusion Shenfu injection combined with chemotherapy is applied in the treatment of small cell lung cancer ,which has a significant effect ,it can obviously improve the patient′s quality of life and lung function ,and it should be promoted and applied in clinical practice .
