Effects of Intervention of Soothing Liver and Activating Blood Chinese Medicine on Cardiac Function and Myocardial Pathologic Morphology of BMSCs Transplanting Myocardial Ischemia Reperfusion Injury Rats
10.3969/j.issn.1005-5304.2014.08.015
- VernacularTitle:疏肝活血中药对骨髓间充质干细胞移植心肌缺血再灌注损伤大鼠心功能和心肌病理形态的影响
- Author:
Xinhui LI
;
Zhengde HUANG
;
Xuejiao XIE
;
Liqing SU
;
Yirong HE
;
Yajing LI
- Publication Type:Journal Article
- Keywords:
soothing liver and activating blood Chinese medicine;
BMSCs;
IRI;
heart function;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(8):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of intervention of soothing liver and activating blood Chinese medicine on cardiac function and myocardial pathologic morphology of BMSCs transplanting on myocardial IRI of rats, and investigate its myocardial protection mechanism. Methods Model of myocardial IRI was established by coronary artery ligation in rats. SD rats were randomly divided into sham operation group, IRI group, BMSCs group and combined group. Rats in combined group were filled the stomach with soothing liver and activating blood Chinese medicine, and rats in other groups were filled the stomach with the same dose of normal saline. After 4 weeks, myocardial pathologic morphology was observed with light microscope. Cardiac function was detected with ultrasonic cardiogram.Results Compared with BMSCs group, heart function of the combined group improved, with significant statistical difference (P<0.05,P<0.01). Pathological observation showed that myocardial structure and pathological morphology were obviously promoted in the combined group.Conclusion Soothing liver and activating blood Chinese medicine could improve heart function and myocardial pathological morphology of IRI rats with BMSCs transplantation.
