Comparison of the clinical efficacy and patients compliance of two kinds of insulin therapy for gestational dia-betes mellitus
10.3760/cma.j.issn.1008-6706.2014.15.011
- VernacularTitle:两种胰岛素治疗方案治疗妊娠期糖尿病的临床疗效及患者依从性比较
- Author:
Cheng DUAN
- Publication Type:Journal Article
- Keywords:
Diabetes,gestational;
Insulin;
Therapeutics
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(15):2263-2265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of isophane protamine biosynthetic human insulin premixed 30R( Novolin 30R) and biosynthetic human insulin ( Novolin R) combined with protamine biosynthetic human insulin (Novolin N) in the treatment of gestational diabetes mellitus and the patients compliance .Methods According to the digital table ,40 patients with gestational diabetes mellitus were randomly divided into A group ( 20 cases ) and B group(20 cases).A group was treated with Novolin 30R,while B group was given Novolin R combined with Novolin N.The blood glucose levels,the incidence of hypoglycemia during hospitalization ,clinical efficacy,security,conven-ience of insulin injection and compliance were compared and evaluated in the two groups .Results In A group after treatment,the compliance rate was 70.00%(14/20),that in B group was 75.00%(15/20),there was no significant difference(χ2 =0.125,P>0.05).In A group,the incidence rate of hypoglycemia was 10.00%(2/20),that in B group was 5.00%(1/20),there was no significant difference (χ2 =0.360,P>0.05).After treatment,the fasting blood glucose,postprandial 2 hours blood glucose levels in the two group were decreased significantly ( t =5.883, 5.248,6.856,7.549,all P<0.05),but the differences were not statistically significant between the two groups after treatment [(4.9 ±1.0)mmol/L vs.(4.8 ±1.2)mmol/L,(6.6 ±1.6)mmol/L vs.(6.3 ±1.8)mmol/L,t=0.085, 0.553,all P>0.05].In A group,the incidence rate of irregularly injected insulin was 1.23%(4/324),which was significantly lower than 3.58%(23/642) in B group(χ2 =4.37,P<0.05).Conclusion Novolin 30R program and Novolin R combined with Novolin N program can effectively control the glucose of gestational diabetes ,the clinical re-sults are satisfactory and relatively safe ,but the former is more acceptive by the patients .
