Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration ;in the diagnosis of the bladder malignant lesions
10.3969/j.issn.1007-3969.2014.07.012
- VernacularTitle:18F-FDG PET/CT显像中应用“反复排尿再充盈法”提高膀胱病灶检出率的临床研究
- Author:
Jingyi CHENG
;
Zhongyi YANG
;
Yongping ZHANG
;
Xincun WANG
;
Lingling PAN
;
Yiping ZHU
;
Yingjian ZHANG
- Publication Type:Journal Article
- Keywords:
Urogenital neoplasms;
Positron emission tomography;
Computed X-ray tomography;
18F-lfuorodeoxyglucose
- From:
China Oncology
2014;(7):540-544
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: 18F-FDG has been considered to be of limited value for the detection of bladder lesions because of interference by the 18F-FDG excreted in urine. Delayed pelvic images with“diluted and iflled bladder”use a method of 18F-FDG PET/CT with delayed images after oral hydration so as to increase the detection rate of 18F-lfuorodeoxyglucose(FDG) PET/CT imaging for the lesions of bladder. Methods:48 patients with bladder lesions(35 patients with bladder primary tumor and 13 patients with metastatic tumor) underwent 18F-FDG PET/CT detection and were required oral hydration of 1200-1800 mL water, urination frequently, holding urine when the more scan began. Lesions conifrmed by histopathology, MRI, CT or clinical follow-up at least 1 year. Results:89%(43/48) of patients were obtained good clearance and the urine SUVmax declined from 33.14(9-66.80)to 3.23(1.35-5.65) signiifcantly and the statistical difference was signiifcant (t=8.703, P<0.01). The interval time between two scan was 2 h approximately. At the same time, the SUVmax of bladder lesion was 2.8-25.0. Detection sensitivity, speciifcity and accuracy were 90.47%(19/21), 81.48%(22/27)and 85.41%(41/48), respectively. Conclusion: 18F-FDG activity in the bladder signiifcantly decreased in most patients with“diluted and iflled bladder”. The PET/CT scan can highly detect lesions of bladder tissues. Our method with high accuracy and better endurance could be applied to detect the lesions in bladder.
