The determination and clinical implications of serum brain-derived neurotrophic factor level in depressive patients

VernacularTitle:抑郁症患者血清脑源性神经营养因子水平测定及临床意义
Author: Yongliang LYU ; Hongliang ZHU ; Zhenxiang ZHOU ; Rongsheng ZHANG ; Xiaowen XU ; Xiongwei ZHU
Publication Type:Journal Article
Keywords: Depression; Brain-derived neurotrophic factor
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(14):2084-2085
CountryChina
Language:Chinese
Abstract: Objective To explore the serum levels of brain-derived neurotrophic factor in patients with depression and their correlation with age,gender,age of onset,illness course,depressive severity.Methods Serum BDNF levels in 91 depressive patients and 36 healthy controls were assayed by the ELISA method .The clinical char-acteristics were assessed by the Hamilton Rating Scale for Depression ( HAMD) .Results The serum BDNF levels in depressive patients were (24.38 ±6.27)μg/L,which was significantly lower than (31.44 ±10.72)μg/L in controls (t=3.708,P <0.01) and were unrelated to age,gender,age of onset,illness course,depressive severity (r =-0.034,t=0.068,r =-0.025,0.026, -0.076,P >0.05).Conclusion Serum BDNF levels in depressive patients was decreased and low levels of BDNF in serum may be a state characteristic for depression .