Clinical features of moyamoya disease in children and the efficacy analysis of encephaloduroarterio-synangiosis
11.3969/j.issn.1672-5921.2014.06.002
- VernacularTitle:儿童烟雾病临床特征及其脑硬膜颞浅动脉融通术疗效分析
- Author:
Bing ZHU
;
Xiangyang BAO
;
Lian DUAN
- Publication Type:Journal Article
- Keywords:
Moyamoya disease;
Children;
Brain infarction;
Prognosis;
Encephaloduroarteriosy nangiosis
- From:
Chinese Journal of Cerebrovascular Diseases
2014;(6):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of moyamoya disease in children and the prognosis of encephaloduroarteriosynangiosis ( EDAS) . Methods According to the age of first operated patients,317 children with moyamoya disease who received EDAS from January 2004 to December 2010 were divided into 3 groups:infant group (n=16,<3 years of age),preschool group (n=42,3 to 6 years of age),and adolescent group (n=259,6 to 17 years of age). The clinical data and the efficacy of operation of the patients were analyzed retrospectively. Results (1) Among the 3 groups of patients,the incidences of cerebral infarction in the infant group (81. 2%,13/16) or the preschool group (69. 0%,29/42) before procedure were significantly higher than the adolescent group (48. 3%,125/259). There were significant differences (χ2 =11. 741,P<0. 01). (2) Before surgical intervention,the infarct volume enlargement or the recurrence of infarction rate at different parts of brain in the infant group (62. 5%,10/16) was higher than that of the preschool group (31. 0%,13/42) and adolescent group (3. 9%,10/259). There was significant difference (χ2 =77. 437,P <0. 01). (3) The overall rate of favourable prognosis was 86. 4% (274/317). There were significant differences between the 3 groups (χ2 =9. 026,P<0.02). Conclusion The conditions of children with moyamoya disease progresses rapidly and their clinical prognosis is poor. It is safe and effective to perform EDAS early moyamoya disease in children.
