Clinical significance of detection of serum procalcitonin and high-sensitivity C-reactive protein in AECOPD
10.3969/j.issn.1673-4130.2014.12.022
- VernacularTitle:降钙素原和超敏C反应蛋白检测在慢性阻塞性肺疾病急性加重中的意义
- Author:
Xiaotao YE
;
Xu ZHANG
;
Mingxian ZHANG
- Publication Type:Journal Article
- Keywords:
procalcitonin;
C reactive protein;
chronic obstructive pulmonary disease;
bacterial infection
- From:
International Journal of Laboratory Medicine
2014;(12):1573-1574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of detection of serum procalcitonin(PCT),high sensitivity-C-reactive protein(hs-CRP)and leukocyte in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Methods 45 patients with AECOPD and 50 patients(AECOPD group)with chronic obstructive pulmonary disease(COPD)in slationary phase (COPD group)were selected,and their serum levels of PCT,hs-CRP and leukocyte were tested.Results Before treatment,the con-centrations of PCT and hs-CRP were (3.32±1.81)ng/mL and (22.36±5.03)mg/L in AECOPD group respectively.They were significantly higher than those in COPD group with statistical differences(P<0.01).The positive predictive value of PCT and hs-CRP was 68.9% and 60.0% in AECOPD group respectively,which were significantly higher than those in COPD group(P<0.01).After antibiotic treatment,the leukocyte,PCT,and hs-CRP levels in AECOPD group were significantly lower than those be-fore treatment(P< 0.01).Conclusion In AECOPD patients,PCT and hs-CRP are good diagnostic indexes.
