Advances in research on molecular design of antimicrobial peptides
10.7644/j.issn.1674-9960.2014.05.019
- VernacularTitle:抗菌肽的分子设计研究进展
- Author:
Xingdong LIU
;
Qingbin MENG
;
Qingguo MENG
- Publication Type:Journal Article
- Keywords:
antimicrobial peptides;
molecular design
- From:
Military Medical Sciences
2014;(5):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial peptides ( AMPs) are a kind of micromolecular peptides with antibacterial , antivirus and anti-tumor activities.Unlike conventional antibiotics , acquisition of resistance by a sensitive microbial strain against AMPs is surprisingly improbable .AMPs are not widely used clinically due to their toxicity , susceptibility to proteolysis and high manufacturing cost .Researchers have obtained some AMPs with high activity and low toxicity by structure modifications . The molecular design of AMPs as well as their development in the future are reviewed .
