Progress in the development of metabolic and breast cancer
10.3760/cma.j.issn.1673-4203.2014.06.017
- VernacularTitle:代谢与乳腺癌发生发展的研究进展
- Author:
Lihua ZHENG
;
Mengmeng ZHANG
;
Yaheng ZHAO
;
Yunjiang LIU
- Publication Type:Journal Article
- Keywords:
Metabolism;
Breast neoplasms;
Estrogens;
Adenosine 5'-monophosphate-activated protein kinase
- From:
International Journal of Surgery
2014;41(6):420-423
- CountryChina
- Language:Chinese
-
Abstract:
With the social development,the number of obese people is increasing.Recent studies have shown that obese women to have breast cancer disease's risk is higher than normal body weight,and etabolic disorders growing threat to human health.Estrogen,aromatase have contributed to the occurrence and development of breast cancer after menopause.AMPK is a negative regulator of aromatase,it can inhibit proliferation of cancer cells by metabolic pathways.What's more metformin,resveratrol inhibited proliferation by this route has been confirmed in breast cancer cells.Here,the author do an overview of the role of obesity-related factor for postmenopausal breast tissue estrogen synthesis and metabolic abnormalities affect aromatase expression in breast.
