Effect-site concentration of sufentanil blunting responses to tracheal intubation with video laryngoscope during propofol TCI
10.3969/j.issn.1006-5725.2014.12.041
- VernacularTitle:丙泊酚靶控输注时舒芬太尼抑制视频喉镜插管的效应室浓度
- Author:
Weidong SHAO
;
Bo HU
;
Xingan ZHANG
;
Chuanmu QIAN
;
Bo XU
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Effect-site concentration;
Video laryngoscope
- From:
The Journal of Practical Medicine
2014;(12):1979-1981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To deter mine the effect-site concentration of sufentanil blunting responses to tracheal intubation with video laryngoscope during propofol target controlled infusion (TCI). Methods Twenty-three patients undergoing selective surgery under general anesthesia were enrolled in this study. Induction of anesthesia was initiated by TCI sufentanil at the target effect-site concentration 3 min later , TCI of propofol began at the target plasma concentration of 3 μg/mL. Cisatracurium 0.15 mg/kg was ad ministrated for video laryngoscope tracheal intubation after loss of consciousness. The target concentration of sufentanil for consecutive patients was deter mined using the modified Dixon′s up-and-down method by the intubation response of the previous patient , in an increment or decrement of 0.05 ng/mL. The initial concentration was set at 0.4 ng/mL. Results The EC50 of Sufentanil was 0.32 ng/mL with 95%confidence interval of 0.29~0.35 ng/mL; the EC95 was 0.38 ng/mL with 95%confidence interval 0.35-0.55 ng/mL during video laryngoscope tracheal intubation. Conclusion The EC50 and EC95of sufentanil blunting responses to tracheal intubation with video laryngoscope are 0.32 ng/mL and 0.38 ng/mL during propofol TCI.
