Genetics and pathophysiological mechanisms of moyamoya disease
10.3760/cma.j.issn.1673-4165.2014.04.013
- VernacularTitle:烟雾病的遗传学和病理生理学机制
- Author:
Daobin CHENG
;
Jiede ZHANG
;
Fang LYU
;
Chao QIN
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
Moyamoya Disease;
Genetic Predisposition to Disease;
Angiogenic Proteins;
Endothelial Cells;
Inflammation;
Nitric Oxide
- From:
International Journal of Cerebrovascular Diseases
2014;22(6):458-463
- CountryChina
- Language:Chinese
-
Abstract:
Moyamoya disease (MMD) is a chronic and progressive cerebrovascular disease which is characterized by the bilateral internal carotid artery ends and (or) stenosis or occlusion of anterior cerebral artery and middle cerebral artery initial segments,compensatory proliferation of small blood vessels in the skull base and formation of abnormal vascular network.Its etiology and pathogenesis remains unclear.The present studies speculate that MMD may be a polygenic disease,inflammation,immune response,abnormal cytokine secretion,endothelial progenitor cell change and nitric oxide level change are associated with the occurrence and development of MMD.This article reviews the advances in research on the genetics and pathophysiological mechanism of MMD.
