Interleukin-8 and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2014.04.011
- VernacularTitle:白细胞介素-8与脑缺血
- Author:
Xinchen HUI
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Interleukin-8;
Chemokines;
Neutrophils;
Inflammation;
Neuroprotective
- From:
International Journal of Cerebrovascular Diseases
2014;22(6):450-453
- CountryChina
- Language:Chinese
-
Abstract:
Immuno-inflammation is one of the main pathophysiological mechanisms of ischemic brain injury,of which chemokines and its receptors widely participate in the occurrence and development processes of ischemic brain injury.Interleukin-8 (IL-8) and its receptors participate in the activation and chemotaxis of neutrophils into brain tissue,and may further aggravate cerebral ischemia-reperfusion injury.At present,therapeutic drugs for IL-8 are mainly CXC chemokine receptor 2 antagonists,including narrow and broad-spectrum chemokine antagonists.This article reviews the advances in research on the pathological mechanism and targeting treatment of IL-8 in ischemic brain injury.
