DNA methyctransferase 1 and gynecological malignancies
10.3760/cma.j.issn.1673-422X.2014.06.017
- VernacularTitle:DNA甲基转移酶1与妇科恶性肿瘤
- Author:
Ling WANG
;
Ping JIN
- Publication Type:Journal Article
- Keywords:
Site-specific DNA methyltransferase (cytosine-specific);
Genital neoplasms,female
- From:
Journal of International Oncology
2014;41(6):458-460
- CountryChina
- Language:Chinese
-
Abstract:
DNMT1,the main member of the DNA methyltransferase (DNMT) family,plays a core role in maintaining and regulating tumor cell genome-wide and the local area methylation.DNMT1 is highly expressed in gynecological malignancies,which leads to abnormal DNA methylation of genes,especially high methylation of tumor suppressor genes,gene expression silencing,and malignant cell growth.
