Intra-operative implantation of I125 seeds to treat advanced pancreatic cancer

VernacularTitle:术中放射性粒子植入治疗晚期胰腺癌的疗效
Author: Yang LIU ; Bo SHENG ; Kai JIANG ; Yanbin WANG
Publication Type:Journal Article
Keywords: Pancreatic cancer; Radiotherapy; I125 seeds; Therapeutic effect
From: Chinese Journal of Hepatobiliary Surgery 2014;20(6):446-448
CountryChina
Language:Chinese
Abstract: Objective To study the clinical efficacy of intra-operative implantation of I125 seeds to treat advanced pancreatic cancer.Methods We retrospectively analyzed the clinical data of 28 patients who underwent intra-operative implantation of I125 between January 2009 and June 2010 to treat advanced pancreatic cancer.Patients who received conservative treatment (n =136) at the same period were used as the control group.Results The mean tumor diameter was (5.7 ± 1.7) cm.The average number of implanted seeds were 50.There were no patients who suffered from pancreatic fistula or post-operative bleeding,and no patient died from the treatment.Twenty-five patients were regularly followed up,and the follow-up rate was 85.7％.The survival rates at one month,half a year and one year were 100％,70.8％ and 26.9％,respectively.The average survival time was (9.9 ± 1.4) months.The survival data were significantly higher than that in the control group.Conclusion Intra-operative implantation of I125 seeds was an efficacious treatment for patients with advanced pancreatic cancer.