The expression of P57kip2 and its clinical significance in hilar bile duct adenocarcinoma

VernacularTitle:P57kip2蛋白在肝门部胆管腺癌中的表达及其临床意义
Author: Haibo YU ; Haichuan CHEN ; Feng CHEN ; Xiaodan JIN ; Yi JIANG
Publication Type:Journal Article
Keywords: Hilary bile duct adenocarcinoma; P57kip2 protein; Tumor suppressor gene; Immunohistochemistry
From: Chinese Journal of Hepatobiliary Surgery 2014;20(6):443-445
CountryChina
Language:Chinese
Abstract: Objective To study the expression of P57kip2 and its clinical significance in hilar bile duct adenocarcinoma.Methods The expressions of P57kip2 in hilar bile duct adenocarcinoma tissues (37 cases) and normal bile duct tissues (32 cases) were determined by immunohistochemical SP methods.The relations between the expression levels of P57kip2 with clinicopathologic parameters were analyzed.Results The positive rate of P57kip2 was 43.2％ (16/37) in bile duct adenocarcinoma,while it was 87.5％ (28/32) in normal duct tissues (P ＜0.01).The expression level of P57kip2 in adenocarcinoma showed no significant association with gender,age or CA19-9 level (P ＞0.05),but they were significantly related with lymph node metastasis,invasion and degree of differentiation (P ＜ 0.05).Conclusions P57kip2 is associated with the occurrence and development of hilar bile duct adenocarcinoma.It may play an important role in invasion and metastasis of hilar bile duct adenocarcinoma.The P57 protein can be used as an index to diagnose hilar bile duct adenocarcinoma.