The effect of Huolisu oral liquid combined with mirtazapine tablets on the expression of NE,5-HT in the patients with depression
10.3760/cma.j.issn.1673-4246.2014.06.015
- VernacularTitle:活力苏口服液联合米氮平对气血亏虚型抑郁症患者血清去甲肾上腺素及5-羟色胺的影响
- Author:
Xiaoli FU
;
Shulan PANG
- Publication Type:Journal Article
- Keywords:
Huolisu oral liquid;
Mirtazapine;
Depression;
NE;
5-HT
- From:
International Journal of Traditional Chinese Medicine
2014;(6):528-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Huolisu oral liquid combined with mirtazapine tablets on the expressions of NE and 5-HT in the patients with depression,and explore the therapeutic efficiency. Methods 75 patients with depression were randomly divided into a study group with 43 cases,which were treated with Huolisu oral liquid and mirtazapine tablets and a control group with 32 cases,which were only treated with mirtazapine tablets The Hamilton depression scale(HAMD)score, serum NE,and 5-HT were detected in the patients before the treatment and 4 and 8 weeks after the treatment separately. Results Before treatment,there were no statistical significance in HAMD score,serum depression NE and 5-HT(t=0.501, 0.520, 0.611,P>0.05). After treated for 4 and 8 weeks, compare with the control group, HAMD score was decreased(t=1.829、2.263, P<0.05), serum 5-HT was increased(t=2.119, 2.870, P<0.05),and NE was increased in the study group(t=2.264, 2.705,P<0.05). Conclusion Huolisu oral liquid combined with mirtazapine tablets can significantly decrease HAMD score,and increase serum NE and 5-HT level. The treatment can improve the depression symptoms in the patients with depression obviously.
