Expressions and clinical significance of p33ING1b and p53 in psoriasis and basal cell carcinoma

VernacularTitle:p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义
Author: Qi HE ; Qing YUE ; Xianming PI ; Quan SHI ; Hongxiang CHEN ; Jiawen LI
Publication Type:Journal Article
Keywords: p53; p33ING1b; Psoriasis; Basal cell carcinoma; Inhibitor of growth 1 gene
From: The Journal of Practical Medicine 2014;(9):1391-1394
CountryChina
Language:Chinese
Abstract: Objective To discuss the expressions and clinical significance of p53 and p33ING1b in human psoriasis and basal cell carcinoma (BCC). Methods Immunohistochemistry EnVision technique was used to detect the expressions of p53 and p33ING1b in samples of 36 psoriasis vulgaris, 28 BCC and 14 normal skins. Results The expression of p53 increased while p33ING1b had a degressive expression in the control group, the psoriasis group and the BCC group. It was found significant statistical difference between the two groups (all P < 0.05). Prominent positive correlation between p53 and p33ING1b were found in both psoriasis group and BCC group (all P<0.05). Conclusions p53 coacts with p33ING1b at local lesions of abnormal proliferative diseases . It′s one of the most prominent mechanisms contributing to deviant cell proliferation.