Association between human papilloma virus late 1 protein and high risk human papilloma virus persistent infection in cervical intraepithelial neoplasia
10.3969/j.issn.1006-5725.2014.09.023
- VernacularTitle:人乳头瘤病毒L1壳蛋白与宫颈上皮内瘤变治疗后高危型人乳头瘤病毒持续感染的相关性
- Author:
Li LIU
;
Yumei CHEN
;
Qingyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Human papillomavirus late 1 protein;
Cervical intraepithelial neoplasia;
High-risk human papillomavirus
- From:
The Journal of Practical Medicine
2014;(9):1417-1419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possibility of human papillomavirus late 1 (HPV-L1) protein detection in predicting the prognosis of cervical intraepithelial neoplasia (CIN). Methods (1)Through immunocytochemical method to detect expression of HPV-L1 protein in diagnosis of CIN before treatment. (2) Through hybridization and gene chip technology to detect expression of high-risk human papilloma virus (HR-HPV) in diagnosis of CIN after treatment for twelve months. Results (1) Comparing the three treatment methods in CIN patients, HR-HPV infection sustained no significant difference (P > 0.05). (2) The positive expression rate of HPV-L1 protein was 75.00% in CINⅠand 36.13%in CINⅡ~Ⅲbefore treatment, with statistically significant (P<0.05). (3) Persistent infection rate of HR-HPV was 5.97%in HPV-L1 positive expression group after treatment for twelve months and 19%in HPV-L1 negative expression group. The difference between the two was statistically significant (P<0.05). (4) The expression of HPV-L1 capsid protein before treatment had a negative relationship with HR-HPV persistent infection after 12 months of treatment. Conclusion Detection of HPV-L1 protein before treatment can predict the prognosis of CIN which had been treated.
