Recent effect of warfarin anticoagulant therapy for 130 elderly cases after heart biological valve replacement in Yunnan-Guizhou plateau
10.3969/j.issn.1006-5725.2014.09.048
- VernacularTitle:云贵高原地区老年心脏生物瓣膜置换术后华法林抗凝治疗130例的近期效果
- Author:
Yinqiang LIU
;
Jie TAO
;
Baihui YANG
;
Jianmin XIA
;
Xueyu ZHANG
;
Guimin ZHANG
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis;
Anticoagulant therapy;
Warfarin;
Yunnan-Guizhou plateau
- From:
The Journal of Practical Medicine
2014;(9):1490-1492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reasonable anticoagulant therapy for patients over sixty five years old in Yunnan-Guizhou plateau after heart biological valve replacement , and study the standard of reasonable anticoagulant therapy. Methods We collected the recent cases by retrospective way . Low-intensity anticoagulation standard INR (1.5~2.5) was used on 130 patients over sixty five years old. The warfarin dose and anticoagulation INR values in different surgery operation were compared when the patients reached the stable anticoagulation status. The frequency of INR values and warfarin dosage were studied. The differences between the patients with high risk factors and the ordinary patients without the high risk factors in INR values and warfarin dosage were investigated. Results The INR values and warfarin doses showed no significant difference (P > 0.05) in different operation groups when they reached stable anticoagulation status. The INR values was 1.94 ± 0.50 and the daily warfarin dose was (2.45 ± 0.82)mg/d. No significant differences in INR values and warfarin doses were found between the high-risk group and the general group (P>0.05) in steady-state. During follow-up, both the incidence rate of thrombosis and general bleeding were 0.77%. Conclusion The precent study showed that the low-intensity anticoagulation INR values (1.5~2.5) can be the standard of reasonable anticoagulation in Yunnan-Guizhou plateau after heart biological valve replacement with satisfactory anticoagulant effect.
