Evaluation of anticoagulant efficacy and safety for domestic bivalirudin during percutaneous coronary intervention in elderly patients with acute coronary syndrome
10.3969/j.issn.1004-8812.2014.05.010
- VernacularTitle:比伐卢定在高龄急性冠状动脉综合征患者经皮冠状动脉介入治疗中的应用体会
- Author:
Meng ZHANG
;
Na LI
;
Lei WANG
;
Yalei HAN
;
Dongdong ZHAI
;
Weihua JIN
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Bivalirudin;
Acute coronary syndrome;
Senile
- From:
Chinese Journal of Interventional Cardiology
2014;(5):318-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of bivalirudin during perioperation of percutaneous coronary intervention (PCI) in patients older than 80 years old with acute coronary syndrome. Methods A total of 64 patients were randomly divided into two groups, respectively received heparin(n=32), or bivalirudin (n=32). We compared the activated coagulation time (ACT), procedural success rate, bleeding rate between two groups. Results The two groups ACT, PCI success rates are not statistically different, No signiifcant difference in the incidence of mild hemorrhage which is 4 (12.5%) for heparin and 1(3.1%) for bivalirudin and severe bleeding which is 2 (6.2%) for heparin and 0 for bivalirudin. However there are signiifcant differences in the overall incidence of bleeding between the two groups with lower incidence of beeding in the bivalirudin group than the heparin group (P<0.05). Conclusions Bivalirudin has comparable anticoangulation effect as heparin during perioperation of percutaneous coronary intervention (PCI) among patients older than 80 years of age with acute coronary syndrome with lower bleeding incidence than heparin dose.
