Future perspectives and challenges in the development of an antitumor vaccine based on heat shock protein gp96-peptide complex
10.3969/j.issn.1000-8179.20140327
- VernacularTitle:热休克蛋白gp96-肽复合物肿瘤疫苗的应用前景与挑战
- Author:
Changying LI
;
Jiwu CHANG
- Publication Type:Journal Article
- Keywords:
gp96-peptide complex;
tumor vaccine;
immune response;
further perspective;
challenge
- From:
Chinese Journal of Clinical Oncology
2014;45(11):738-740
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) containing tumor antigenic peptides can elicit po-tent tumor-specific and protective immunity. Autologous HSPPC-96 vaccine has been shown to effectively prolong recurrence-free sur-vival and increase the overall survival of many tumors, thereby suggesting extensive future applications. However, as an autologous tu-mor-derived individual vaccine, the development of HSPPC-96 vaccine is challenged by the lack of an adequate autologous tumor, lim-ited efficacy for advanced-stage cancer, etc. This paper summarized the progress, future perspectives, and challenges in the clinical de-velopment of HSPPC-96 vaccine immunotherapy.
