Comparing tonifying blood effects of Danggui-Honghua with different proportions on blood deficiency mice
10.3969/j.issn.1001-1978.2014.06.029
- VernacularTitle:当归-红花不同配比对血虚小鼠补血作用的比较研究
- Author:
Shujiao LI
;
Yuping TANG
;
Weixia LI
;
Juan SHEN
;
Jianming GUO
;
Jinao DUAN
- Publication Type:Journal Article
- Keywords:
Danggui;
Honghua;
compatibility propor-tion;
blood deficiency;
nourishing and tonifying blood;
multi-attribute comprehensive index method
- From:
Chinese Pharmacological Bulletin
2014;(6):874-879
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the differences of tonify-ing blood effect for the combination of Danggui and Honghua ( GH) with different proportions on blood de-ficiency mice, and choose the proportion of GH which has the optimal tonifying blood effect. Methods The blood deficient mice model was induced by injection of phenylhydrazine and cyclophosphamide. On the basis of multi-attribute comprehensive index method, the op-timal dose was determined through three doses of GH 1: 1 , which was the highest frequency proportion of GH used in the “Dictionary of Chinese Medicine Prescrip-tions”. According to the optimal dose, the change reg-ulation of tonifying blood effect of GH with different proportions was observed. Results Among three do-
ses (1, 3 and 5 times of clinical dose), the tonifying blood effect of GH was best when the dosing concentra-tion of GH was clinical dose. Among nine proportions (1 : 0, 4 : 1, 2 : 1, 3 : 2, 1 : 1, 2 : 3, 1 : 2, 1 : 4 and 0 : 1), GH 1 : 1 had the best effect. Conclusion The results are consistent with regulations of medi-cine usage that GH 1 : 1 has the highest frequency used in Herbal Formulae, which could provide scientif-ic basis for more effective application of Danggui and Honghua in modern clinic medicine.
