Relationship between serum 1,25(OH)2D3 and oxidative stress in patients with diabetic nephropathy

VernacularTitle:糖尿病肾病患者血清1，25二羟维生素D3水平与氧化应激的关系
Author: Xiaojun LI ; Yingying ZHANG ; Lu FANG ; Hualin QI ; Shougang ZHUANG ; Haidong YAN
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Oxidative stress
From: Chinese Journal of General Practitioners 2014;(6):480-482
CountryChina
Language:Chinese
Abstract: To explore the relationship between serum 1,25(OH)2D3 and oxidative stress in patients with diabetic nephropathy (DN).The serum levels of 1,25(OH)2D3 in DN patients were significantly lower than those in DM and healthy controls.And the 1,25(OH)2D3 level was negatively correlated with advanced oxidation protein products ( AOPP ) , reactive oxygen species ( ROS ) and positively correlated with superoxide dismutase (SOD) in DN patients.1,25(OH)2D3, low density lipoprotein-cholesterol (LDL-C), body mass index ( BMI) , serum creatinine and age were associated with the level of oxidative stress in DN patients.With the progression of CKD , the serum levels of AOPP and ROS increased significantly while those of SOD and 1,25(OH)2D3 decreased markedly.