Sniffin’ Sticks test in evaluating olfactory function in Parkinson’ s disease
10.3760/cma.j.issn.1006-7876.2014.06.004
- VernacularTitle:Sniffin ’ Sticks 方法评价帕金森病患者的嗅觉功能
- Author:
Yi LUO
;
Ying WAN
;
Jing GAN
;
Rongguo HU
;
Yun HUA
;
Zhenguo LIU
;
Mengyuan QU
;
Weidi SHEN
;
Yarong WEI
;
Xiaoyu REN
- Publication Type:Journal Article
- Keywords:
Parkinson’s disease;
Smell;
Olfactory disorders;
Sensory thresholds;
Odors
- From:
Chinese Journal of Neurology
2014;(6):370-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the olfactory function and its influence factors by using Sniffin ’ Sticks test, and to compare the quality of Parkinson ’s disease (PD) recognition between Sniffin’ Sticks and 16 kinds of odor identification in Sniffin ’ Sticks(SS-16) tests.Methods The Sniffin’Sticks test was used to assess the olfactory function of 68 PD patients and 76 healthy volunteers , and the relationship between smell and age, disease duration, Unified Parkinson’ s Disease Rating Scale score, Hoehn-Yahr (H-Y) rating, and cognitive function level (Montreal Cognitive Assessment) was analyzed.Results (1)The prevalence of olfactory dysfunction in PD group (83.3%) was significantly higher than that in control group (21.2%).The Sniffin’ Sticks test showed that the odor threshold score (6.6 ±3.2, P=0.000), odor discrimination score (6.6 ±3.3, P=0.000), 16 kinds of odor identification score (6.8 ±2.4, P=0.000) in PD group were significantly lower than those in control group.( 2 ) When comparing the PD cases and healthy controls in recognition , the sensitivity and the specificity of the Sniffin ’ Sticks test were 0.897 and 0.737, respectively, similar to the SS-16 test.However, the Sniffin’ Sticks test showed advantage compared with odor threshold and odor discrimination.( 3 ) The olfactory score in PD group was positively correlated with cognitive function (r=0.243, P=0.046), and was unrelated with age, gender, disease duration, and disease severity.The olfactory score in control group was negatively correlated with age (r=-0.270, P=0.018), but positively correlated with cognitive function (r=0.281, P=0.014).Conclusions There is a higher incidence of olfactory dysfunction in PD patients than in control group.Sniffin’ Sticks test is superior to SS-16 test in quantitative and qualitative analysis of olfactory function in PD patients.Two tests both have high sensitivity and specificity in the recognition of PD .
