The status of research on estimated glomerular filtration rate and its challenges
10.3760/cma.j.issn.1009-9158.2014.06.003
- VernacularTitle:肾小球滤过率评估方程的研究现状和面临的挑战
- Author:
Ling QIU
;
Xiuzhi GUO
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,chronic;
Glomerular filtration rate;
Creatinine;
Cystatin C;
Reference standards
- From:
Chinese Journal of Laboratory Medicine
2014;(6):404-407
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease ( CKD ) is a worldwide public health problem.Glomerular filtration rate ( GFR ) is a key indicator for early diagnosis and accurate classification of CKD , how to estimate GFR accurately and conveniently has been a difficulty and hot-points.We describes the development of several major eGFR equations based on creatinine and cystatin C , analysis the impact of the different research methods on performance of equation , and discusses the issue in research and application of eGFR in China.Accordingly make the following recommendations ( 1 ) Expand the study size ( multiple centers) and participants number , then develop and validate eGFR equations based on Chinese population ;(2) Standardize the gold standardof GFR in the study and unify the analysis and evaluation methods;(3) Promote the consistency and standardization of creatinine and cystatin C which is the basis for the wide range of applications of the eGFR formula.
