Role of macrophage polarization in atherosclerosis and its drug target
10.3969/j.issn.1001-1978.2014.06.003
- VernacularTitle:巨噬细胞极化在动脉粥样硬化中的作用和药物靶标
- Author:
Tiantian ZHU
;
Ju DUAN
;
Liuqiang ZHANG
;
Shuang LING
;
Yiming LI
;
Jinwen XU
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
inflammation;
macrophage polari-zation;
M1 macrophages;
M2 macrophages;
drug targets
- From:
Chinese Pharmacological Bulletin
2014;(6):748-751
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a complex metabolic cardiovascular disease. such inflammatory phenomena as the invasion of lipid into the arterial intima and accumulation, the increase of foam cells, the exacerbation of inflammatory lesions, plaque necrosis and disintegration, ulcer bleeding and thrombosis, fibrosis and calcification, etc, are basic pathological characteristics of ather-osclerosis. In this process, macrophages and T lymphocytes play an important role. In recent years,atherosclerosis pathology re-search mainly focuses on the role of macrophage polarization.
Basically,macrophage can be divided into two subtypes: classi-cal activation macrophage M1 and alternative activation macro-phage M2. Therefore to paper reviews the meaning of M1 and M2 macrophage polarization during atherosclerosis, regulatory pathways and drug targets research status to provide new direc-tion for innovative drugs and disease treatment.
