Relationship between polymorphisms in IGF-1 and IGFBP-3 and non-smoking female lung cancer
10.3969/j.issn.1000-8179.20140543
- VernacularTitle:IGF-1和IGFBP-3基因多态性与非吸烟女性肺癌关联研究
- Author:
Jinyu KONG
;
Xu WANG
;
Fangxiu XU
;
Jinli QU
;
Biyun QIAN
- Publication Type:Journal Article
- Keywords:
IGF-1;
IGFBP-3;
single-nucleotide polymorphism;
nonsmoking female lung cancer;
risk factors
- From:
Chinese Journal of Clinical Oncology
2014;45(11):697-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to investigate the associations between single-nucleotide polymorphism (SNP) of IGF-1 and IGFBP-3 gene and risk of non-smoking female lung cancer in Chinese population. Methods:Genotyping was performed using the TaqMan method in 287 histologically confirmed non-smoking female lung cancer cases and 281 healthy controls. Results:The geno-type distributions of IGF-1 polymorphisms were significantly different between cases and controls (P<0.001). Analysis of multivariate logistic regression showed that the carriers of the CC genotype exhibited a significantly decreased risk of lung cancer in non-smoking female (adjusted OR=0.28, 95%CI:0.15-0.54). IGF-1 rs1520220 GG genotype may reduce the risk of advanced lung cancer incidence in nonsmoking female (adjusted OR=0.30, 95%CI:0.09-0.96). Log-rank test and Cox regression analyses revealed that variant geno-types of IGF-1 rs2946834 CT/TT had a significantly decreased lung cancer mortality risk compared with the homozygote CC in≥60 age group or patients with a lung tumor>3 cm. Conclusion:The IGF-1 polymorphism was associated with the risk of lung cancer and prognosis among non-smoking female. More rigorous laboratory studies of large sample population and functional studies are warrant-ed to confirm our findings.
