Macrophage Polarization and Its Role in Development of Atherosclerosis
10.11842/wst.2014.05.039
- VernacularTitle:巨噬细胞极化及其在动脉粥样硬化发生发展中的作用
- Author:
Bingbing ZHOU
;
Yujie LI
;
Qi LI
;
Qing YANG
;
Xiaogang WENG
;
Ying CHEN
;
Yajie WANG
;
Yan GUO
;
Xucen LIU
;
Zipeng GONG
;
Xiaoxi KAN
;
Ruijie ZHANG
;
Xiaoxin ZHU
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
monocyte-macrophage;
macrophage polarization;
M1 macrophages;
M2 macrophages
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(5):1065-1070
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis (As) is an important pathological basis of cardiovascular and cerebrovascular diseases. The pathogenesis studies of As have been a hot topic in the field of vascular biology research. The inflammation is known as a major participant in the development process of As. And monocyte-macrophage plays a central role in inflam-mation. In recent years, with the deepening research on inflammatory mechanisms, the As macrophage polarization is attracting researchers' attention. Under different environmental inductions, macrophages develop into M1 and M2 phenotypes. M1 macrophages (classical type), which can stimulate the secretion of pro-inflammatory cytokines, is generally considered as pro-inflammatory subtypes and can facilitate the progress of As. Whereas, M2 macrophages (alternative type), which can inhibit pro-inflammatory factor production, function as anti-inflammatory subtypes and likely to inhibit the progression of As. The mechanisms of As, macrophage polarization in As, and opportunities for herbal medicines will be summarized in this review.
