The trial of penehyclidine hydrochloride combined with atropine in treatment of patients with severe acute organophosphorus poisoning
10.3969/j.issn.1008-9691.2014.03.012
- VernacularTitle:盐酸戊乙奎醚联合阿托品救治重度急性有机磷农药中毒的疗效观察
- Author:
Linmin LIU
;
Bin CHEN
;
Huabin CHEN
;
Zhongqiu LU
- Publication Type:Journal Article
- Keywords:
Periehyclideine hydrochloride;
Atropine;
Acute poisoning;
Organophoaphorus pesticide
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2014;(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of penehyclidine hydrochloride(Changtuoning)combined with atropine in treatment of patients with severe acute organophosphorus poisoning(AOPP). Methods The clinical data of 64 patients with severe AOPP admitted into Taizhou Municipal Hospital in Zhejiang Province and Quannan County People's Hospital in Jiangxi Province from January 2004 to September 2012 were retrospectively analyzed. Patients were divided into penehyclidine hydrochloride and atropine combined group(PH-A group,32 cases)and atropine treatment group(32 cases)depending on the difference in selection and application method of anticholinergic drugs. The application of anticholinergic drugs,length of mechanical ventilation,70%cholinesterase (ChE)activity recovery time,length of stay in hospital,incidence of complications,and cure rate were compared between the two groups. Results Compared with atropine treament group,the total usage of atropine in PH-A group was significantly decreased(mg:35.39±45.76 vs. 105.46±139.87,P<0.05),the length of mechanical ventilation (days:5.3±4.2 vs. 7.8±6.8,P<0.05),70%ChE activity recovery time(days:8.2±3.8 vs. 11.0±5.4,P<0.05), and length of stay in hospital(days:12.0±3.8 vs. 14.6±5.3,P<0.05)were significantly shortened in PH-A group, and the overall incidence of complications were significantly lowered in PH-A group〔68.75 %(22/32)vs. 93.75%(30/32),P<0.05〕. The difference in cure rate between the combined group and atropine treatment group was not statistically significant〔96.87%(31/32)vs. 90.62%(29/32),P>0.05〕. Conclusion Penehyclidine hydroehloride combined with atropine in the treatment of severe AOPP can significantly improve the therapeutic efficacy,reduce the incidence of complications and length of stay in hospital.
