Study on Intervention Effect of Sang-Ji Mixture in TLR-4 Expression on Peripheral Blood Monocytes in Hypertensive Patients with Overabundant Liver-fire and Phlegm Syndrome
10.11842/wst.2014.05.025
- VernacularTitle:桑蒺合剂干预高血压病（肝火亢盛夹痰证）患者外周血单核细胞表面TLR4表达
- Author:
Keke ZUO
;
Mingjun ZHANG
;
Ning GU
- Publication Type:Journal Article
- Keywords:
Hypertension;
overabundant liver-fire and phlegm syndrome;
Sang-Ji mixture;
TLR-4;
immune function
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(5):1103-1107
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the effect of Sang-Ji (SJ) mixture in the treatment of Toll-like receptor 4 (TLR-4) expression on peripheral blood monocytes (PBMCs) in hypertensive patients. A total of 60 cases of hyper-tensive cases with overabundant liver-fire and phlegm syndrome were randomly divided into the treatment group and the control group with 30 cases in each group. Both groups received Felodipine and/or Benazapril treat-ment. The treatment group was added with SJ mixture. The observation duration was 28 days. The detection was made on indicators such as blood pressure , traditional Chinese medicine ( TCM ) syndrome scores and TLR-4 ex-pression on PBMCs before and after treatment. The results showed that after treatment, the blood pressure, TCM syndrome scores and TLR-4 expression on PBMCs of both groups decreased compared with that of the pretreat-ment . Changes on TCM syndrome scores and TLR-4 expression of the treatment group were more significant than that of the control group ( P < 0 . 05 ) . It was concluded that SJ mixture improved clinical symptoms in pa-tients with overabundant liver-fire and phlegm syndrome , decreased TLR-4 expression on PBMCs , in order to inhibit the immune response to a certain extent .
