Optimization of Preparation Process for 5, 7, 3', 4'-O-tetramethylquercetin

VernacularTitle:5，7，3’，4’-O-四甲基槲皮素的制备工艺优化
Author: Zhonglei WANG ; Liyan YANG ; Xiaohua ZHANG
Publication Type:Journal Article
Keywords: 5,7,3',4'-O-tetramethylquercetin; preparation process; single factor test; orthogonal test
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(5):1182-1187
CountryChina
Language:Chinese
Abstract: This study was aimed to optimize optimum preparation process of 5,7,3',4'-O-tetramethylquercetin (TMQ). With 5,7,3',4'-O-tetramethylrutin as raw material, TMQ was prepared by acidic aqueous solution method. The preparation process of TMQ was optimized by single factor test and orthogonal test. The results showed that the optimum technology conditions were ethanol concentration at 0, temperature at 80℃, hydrochloric acid concentration at 0.50%, and the hydrolysis time for 1.0 h. It was concluded that the optimum preparation process had the charac-teristics of high yield, simple process, stable and feasible.