A clinical study on rectal administration of Kangfei Sanjie decoction for treatment of patients with non-small cell lung cancer
10.3969/j.issn.1008-9691.2014.03.008
- VernacularTitle:康肺散结汤直肠给药治疗非小细胞肺癌的临床研究
- Author:
Jinbo ZHANG
- Publication Type:Journal Article
- Keywords:
Kangfei Sanjie decoction;
Rectal administration;
Non-small cell lung cancer
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2014;(3):190-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of application of differentiation of traditional Chinese medicine(TCM)syndrome and rectal administration of TCM decoction for treatment of patients with non-small cell lung cancer(NSCLC)and its influence on chemotherapy toxic side effects. Methods Seventy-two patients with NSCLC were randomly divided into two groups:the chemotherapy alone group and rectal administration group(each 36 cases). Both groups received chemotherapy,and the rectal administration group additionally took the rectal administration of self made Kangfei Sanjie decoction(composition:ephedra 6 g,forsythia 20 g,citrus aurantium 20 g,platycodon root 10 g,almonds 10 g,rhubarb charcoal 6 g,scutellariae barbatae 30 g,hedyotic diffusa 30 g,actinidiae 15 g, fritillariae thunbergii 10 g,angelica 10 g,asarum 3 g,mirabilitum depuratum 6 g),and according to the patient's individual situation,the ingredients of the decoction could be added or subtracted to perform pulverization enema, once a day,21 days constituting one therapeutic course. After two cycles of chemotherapy,the changes of tumor lesions,KPS score and the occurrence and degree of chemotherapy adverse reaction were observed. Results The total therapeutic efficiency of rectal administration group was higher than that of chemotherapy alone group,but there was no significant difference between them(63.89% vs. 55.56%,P>0.05);the KPS score of rectal administration group was apparently higher than that of chemotherapy alone group(89.52±10.25 vs. 83.17±8.08,P<0.05). The occurrences ofⅡ-Ⅲdegree adverse reaction after chemotherapy of the rectal administration group was significantly less than those of the chemotherapy alone group:leukopenia(4 cases vs. 11 cases),nausea and vomiting(1 cases vs. 6 cases),fatigue(0 vs. 4 cases),hair loss(3 cases vs. 9 cases),the differences between the two groups being statistically significant(all P<0.05). The influence on liver and renal function was not found in two groups(both P>0.05). Conclusion Application of TCM differentiation of syndrome and rectal administration of TCM drug, Kangfei Sanjie decoction,can significantly improve the quality of life of NSCLC patients,reduce toxic side effects of chemotherapy,and the method is simple and inexpensive.
