Study of interleukin-18,interleukin-10 and matrix metalloproteinase-9 levels in restenosis after percutaneous coronary intervention
10.3969/j.issn.1673-4130.2014.11.023
- VernacularTitle:冠心病 PCI 术后再狭窄患者 IL-18、IL-10和基质金属蛋白酶-9水平的研究
- Author:
Yongsheng LIU
;
Hua JIANG
;
Wenwei LIU
;
Ting LI
;
Dengming ZHOU
- Publication Type:Journal Article
- Keywords:
interleukin-18;
interleukin-10;
matrix metalloproteinase-9;
coronary artery disease;
in-stent restenosis
- From:
International Journal of Laboratory Medicine
2014;(11):1431-1432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of IL-18,IL-10 and MMP-9 in coronary heart disease(CAD)patients with in-stent restenosis(ISR)after percutaneous coronary intervention (PCI)treatment,so as to discuss the influence of inflammatory fac-tors to ISR after PCI.Methods CAD patients with ISR after PCI were angiographically re-evaluated and formed the ISR group(n=68)and the non-ISR group(n=173)based on the presence or absence of ISR.109 subjects without angiographic evidence of CAD formed a reference control group(control group).The plasma IL-18,IL-10 and MMP-9 concentrations of subjects were measured. Results The concentrations of serum IL-18 and MMP-9 in ISR group and non-ISR group were significantly higher than control group,while IL-10 level was the opposite.Contrasted with non-ISR group,the concentrations of serum IL-18 and MMP-9 in ISR group were significantly higher,but IL-10 level was the opposite too.There were significantly statistical differences(P <0.05)Con-clusion There is significant correlation between ISR and serum levels of IL-18,IL-10 and MMP-9.The inflammation may have im-portant impact on the process of ISR.
